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TREM2 protein seems to protect brain cells from toxic TDP-43 protein

Abnormal, aggregated forms of TDP-43 protein play a role in the development of certain brain diseases, such as amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, and frontotemporal dementia (FTD). Recently, NIA-supported Mayo Clinic researchers discovered that TREM2, a protein found on certain immune cells, can help protect the brain from TDP-43-related harm. The… Continue reading TREM2 protein seems to protect brain cells from toxic TDP-43 protein

Amyloid structure linked to different types of Alzheimer’s disease

Cutting edge imaging shows that the amyloid fibers in plaques, a hallmark of Alzheimer’s disease, have different molecular structures. NIA-supported research published in Science shows new, high-resolution images of the molecular pieces, called filaments, which make up amyloid plaques in different types of Alzheimer’s and in other degenerative brain conditions. Amyloid plaques form in the brains of… Continue reading Amyloid structure linked to different types of Alzheimer’s disease

Antioxidant Effects on Dementia Risk May Differ

Around 6 million Americans are currently living with Alzheimer’s disease or another type of dementia. That number is expected to rise substantially over the next several decades as the population ages. These conditions, which affect the ability to remember, think, and make decisions, are devastating to patients as well as their families and communities. Studies… Continue reading Antioxidant Effects on Dementia Risk May Differ

Loss of smell linked to Alzheimer’s cognitive impairment and biomarkers

Decline in sense of smell is connected to faster buildup of Alzheimer’s disease-related pathology seen in brain scans, according to new research focused on older adults who live outside of nursing homes. The findings provide additional evidence that loss of smell (known as anosmia) is a key early sign of Alzheimer’s-related cognitive impairment and the… Continue reading Loss of smell linked to Alzheimer’s cognitive impairment and biomarkers